产品货号：
Z34231
中文名称：
TBC1D4抗体
英文名称：
Anti-TBC1D4 Antibody (Clone#OTI5E6)
产品规格：
50μl|100μl|150μl
发货周期：
1～3天
产品价格：
询价
| 抗体名称 | Anti-TBC1D4 Antibody (Clone#OTI5E6) |
| 指标别名 | TBC1D4;AS160;KIAA0603;TBC1 domain family member 4;Akt substrate of 160kDa;AS160 |
| 克隆性 | Monoclonal |
| 检验物种 | human,mouse,rat |
| 应用范围 | WB,IF,FCM |
| 基因名称 | TBC1D4 |
| 克隆号 | OTI5E6 |
| 抗体来源 | Mouse |
| 抗体类型 | IgG2b |
| 免疫原 | Full length human recombinant protein of human TBC1D4 (NP_0055647) produced in HEK293T cell. |
| 实际分子量 | 146.4KD |
| 成分 | PBS (PH 7.3) containing 1% BSA,50% glycerol and 0.02% sodium azide. |
| 纯化方式 | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| 浓度 | 0.35mg/mL |
| 产品形态 | 溶液 |
| 保存条件 | Stable for 12 months from date of receipt.Store at -20℃ as received. |
| 背景资料 | AS160?(Akt substrate of 160kDa),which was originally known as?TBC1 domain family member 4?(TBC1D4),?is a Rab?GTPase-activating?protein?that in humans is encoded by the?TBC1D4?gene.This gene is a member of the Tre-2/BUB2/CDC16 domain family.This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4),important for removing glucose from the bloodstream into skeletal muscle and fat tissues.Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane,suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions.When exposed to insulin,this protein is phosphorylated,dissociates from GLUT4 vesicles,resulting in increased GLUT4 at the cell surface,and enhanced glucose transport.Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface.Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. |
| Uniprot ID | O60343 |
| 基因名全称 | TBC1 domain family member 4 |
| 蛋白名全称 | TBC1 domain family member 4 |
| 推荐稀释比 | Western blot (WB) 1:2000 Immunofluorescence (IF) 1:100 Flow cytometry (FCM) 1:100 |
相关搜索：TBC1D4抗体，TBC1D4单抗，Anti-TBC1D4 Antibody (Clone#OTI5E6)